Novel biocompatible ionic liquids based on gluconate anion

A sustainable organic synthetic methodology for the preparation of novel biocompatible ionic liquids (ILs) based on gluconate anion has been developed. Four functionalized methylimidazolium cations were efficiently combined with gluconic acid by acid-base neutralization reactions. All salts were obt...

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Bibliographic Details
Main Author: Costa, Alexandra (author)
Other Authors: Forte, Andreia (author), Zalewska, Karolina (author), Tiago, Gonçalo (author), Petrovski, Zeljko (author), Branco, Luis C. (author)
Format: article
Language:eng
Published: 2017
Subjects:
Biocompatible
Gluconate
Ionic liquids
Chemistry(all)
Environmental Chemistry
Online Access:https://doi.org/10.1080/17518253.2014.951695
Country:Portugal
Oai:oai:run.unl.pt:10362/23063
Description
Summary:A sustainable organic synthetic methodology for the preparation of novel biocompatible ionic liquids (ILs) based on gluconate anion has been developed. Four functionalized methylimidazolium cations were efficiently combined with gluconic acid by acid-base neutralization reactions. All salts were obtained as RTILs in high yields (92–98%) and in high purity levels. Proton Nuclear Magnetic Resonance (1H NMR) studies had proved the correct cation/ anion proportion (1:1) and their chemical stability. These novel gluconate ILs can be applied for chemistry, material science, and medicine areas.

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