IFN-gamma-dependent activation of macrophages during experimental infections by Mycobacterium ulcerans is impaired by the toxin mycolactone

Buruli ulcer, caused by Mycobacterium ulcerans infections, is a necrotizing skin disease whose pathogenesis is associated with the exotoxin mycolactone. Despite the relevance of this emergent disease, little is known on the immune response against the pathogen. Following the recent demonstration of...

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Bibliographic Details
Main Author: Torrado, Egídio (author)
Other Authors: Fraga, Alexandra Gabriel (author), Logarinho, Elsa (author), Martins, Teresa G. (author), Carmona, Jenny A. (author), Gama, José B. (author), Carvalho, Maria A. (author), Proença, M. Fernanda R. P. (author), Castro, Antonio G. (author), Pedrosa, Jorge (author)
Format: article
Language:eng
Published: 2010
Subjects:
Animals
Bacterial Toxins
Cells, Cultured
Interferon-gamma
Macrolides
Macrophage Activation
Macrophages
Mice
Mycobacterium Infections, Nontuberculous
Mycobacterium ulcerans
Nitric Oxide
Phagosomes
Science & Technology
Online Access:http://hdl.handle.net/1822/67558
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/67558

Internet

http://hdl.handle.net/1822/67558

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