Coenzyme Q10 partially restores pathological alterations in a macrophage model of Gaucher disease

Background Gaucher disease (GD) is caused by mutations in the GBA1 gene which encodes lysosomal β-glucocerebrosidase (GCase). In GD, partial or complete loss of GCase activity causes the accumulation of the glycolipids glucosylceramide (GlcCer) and glucosylsphingosine in the lysosomes of macrophages...

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Bibliographic Details
Main Author: Mata, Mario de la (author)
Other Authors: Cotán, David (author), Oropesa-Ávila, Manuel (author), Villanueva-Paz, Marina (author), Lavera, Isabel de (author), Álvarez-Córdoba, Mónica (author), Luzón-Hidalgo, Raquel (author), Suárez-Rivero, Juan M. (author), Tiscornia, Gustavo (author), Sánchez-Alcázar, José A. (author)
Format: article
Language:eng
Published: 2017
Subjects:
Gaucher disease
Inflammasome
Efferocytosis
Oxidative stress
Mitochondria
Coenzyme Q10
Online Access:http://hdl.handle.net/10400.1/9015
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/9015

Internet

http://hdl.handle.net/10400.1/9015

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