Analysis of EGFR Overexpression, EGFR gene amplification and the EGFRvIII Mutation in portuguese high-grade gliomas

Background: Patients with malignant gliomas do not respond to any current therapy. Epidermal growth factor receptor (EGFR) controls several oncogenic processes, being frequently up-regulated in gliomas due to overexpression, gene amplification and gene mutation. EGFR inhibitors are being tried in gl...

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Bibliographic Details
Main Author: Viana, Marta Pereira (author)
Other Authors: Lopes, José M. (author), Little, Suzie (author), Milanezi, Fernanda (author), Basto, Diana (author), Pardal, Fernando (author), Jones, C. (author), Reis, R. M. (author)
Format: article
Language:eng
Published: 2008
Subjects:
Amplification
EGFR
EGFRvIII
Glioblastoma
Glioma
Oligodendroglioma
Overexpression
Science & Technology
Online Access:http://hdl.handle.net/1822/8367
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/8367

Internet

http://hdl.handle.net/1822/8367

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