New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum

Background: The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs. Methods: A chemically diverse library of endoperoxides was designed and synthesized. The compounds were screen...

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Bibliographic Details
Main Author: Lobo, Lis (author)
Other Authors: Cabral, Lília (author), Sena, Maria I. (author), Guerreiro, Bruno (author), Rodrigues, António S. (author), de Andrade-Neto, Valter F. (author), Cristiano, Maria Lurdes Santos (author), Nogueira, Fatima (author)
Format: article
Language:eng
Published: 2018
Subjects:
Plasmodium falciparum
Trioxolane–tetrazole conjugates
Tetraoxane–tetrazole conjugates
In vivo antimalarial activity
Antimalarial drug resistance
Online Access:http://hdl.handle.net/10400.1/10655
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/10655

Internet

http://hdl.handle.net/10400.1/10655

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