Screening Pyridine Derivatives against Human Hydrogen Sulfide-synthesizing Enzymes by Orthogonal Methods

Biosynthesis of hydrogen sulfide (H2S), a key signalling molecule in human (patho)physiology, is mostly accomplished by the human enzymes cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MST). Several lines of evidence have shown a close correlati...

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Bibliographic Details
Main Author: Zuhra, Karim (author)
Other Authors: Sousa, Pedro M.F. (author), Paulini, Giulia (author), Lemos, Ana Rita (author), Kalme, Zenta (author), Bisenieks, Imants (author), Bisenieks, Egils (author), Vigante, Brigita (author), Duburs, Gunars (author), Bandeiras, Tiago M. (author), Saso, Luciano (author), Giuffrè, Alessandro (author), Vicente, João B. (author)
Format: article
Language:eng
Published: 2019
Subjects:
General
SDG 3 - Good Health and Well-being
Online Access:https://doi.org/10.1038/s41598-018-36994-w
Country:Portugal
Oai:oai:run.unl.pt:10362/85152

Internet

https://doi.org/10.1038/s41598-018-36994-w

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