Screening Pyridine Derivatives against Human Hydrogen Sulfide-synthesizing Enzymes by Orthogonal Methods

Biosynthesis of hydrogen sulfide (H2S), a key signalling molecule in human (patho)physiology, is mostly accomplished by the human enzymes cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MST). Several lines of evidence have shown a close correlati...

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Detalhes bibliográficos
Autor principal: Zuhra, Karim (author)
Outros Autores: Sousa, Pedro M.F. (author), Paulini, Giulia (author), Lemos, Ana Rita (author), Kalme, Zenta (author), Bisenieks, Imants (author), Bisenieks, Egils (author), Vigante, Brigita (author), Duburs, Gunars (author), Bandeiras, Tiago M. (author), Saso, Luciano (author), Giuffrè, Alessandro (author), Vicente, João B. (author)
Formato: article
Idioma:eng
Publicado em: 2019
Assuntos:
General
SDG 3 - Good Health and Well-being
Texto completo:https://doi.org/10.1038/s41598-018-36994-w
País:Portugal
Oai:oai:run.unl.pt:10362/85152

Texto Completo

https://doi.org/10.1038/s41598-018-36994-w

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