The era of RNA interference medicines: the clinical landscape of synthetic gene silencing drugs

ABSTRACT - Therapeutic oligonucleotides, such as small interfering RNAs (siRNAs), provide a simple and effective tool to modulate the expression of any gene. siRNAs harness the RNA interference (RNAi) pathway to degrade disease-associated messenger RNAs (mRNAs). The inherent sequence specificity and...

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Bibliographic Details
Main Author: Godinho, Bruno (author)
Other Authors: Khvorova, Anastasia (author)
Format: article
Language:eng
Published: 2020
Subjects:
RNA interference
siRNA
miRNA
Therapeutic oligonucleotides
Gene knockdown
Drug development
ARN interferência
Oligonucleotídios para terapêutica
Desenvolvimento de novos fármacos
Farmacologia
Pharmacology
Online Access:http://hdl.handle.net/10400.21/11331
Country:Portugal
Oai:oai:repositorio.ipl.pt:10400.21/11331

Internet

http://hdl.handle.net/10400.21/11331

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