Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals

We have previously reported that mouse plasmacytoid dendritic cells (DC) produce high levels of IL-12p70, whereas bone marrow-derived myeloid DC and splenic DC produce substantially lower levels of this cytokine when activated with the TLR-9 ligand CpG. We now show that in response to CpG stimulatio...

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Bibliographic Details
Main Author: Boonstra, André (author)
Other Authors: Rajsbaum, Ricardo (author), Holman, Mary (author), Marques, Rute (author), Asselin-Paturel, Carine (author), Pereira, João Pedro (author), Bates, Elizabeth E. M. (author), Akira, Shizuo (author), Vieira, Paulo (author), Liu, Yong-Jun (author), Trinchieri, Giorgio (author), O'Garra, Anne (author)
Format: article
Language:eng
Published: 2006
Subjects:
Adaptor Proteins, Vesicular Transport
Animals
Bone Marrow Cells
CD8 Antigens
CpG Islands
Dendritic Cells
Interleukin-10
Interleukin-12
Macrophages
Mice
Myeloid Cells
Myeloid Differentiation Factor 88
Spleen
Toll-Like Receptors
Science & Technology
Online Access:http://hdl.handle.net/1822/67938
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/67938

Internet

http://hdl.handle.net/1822/67938

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