Glutathione and the redox control system trypanothione/trypanothione reductase are involved in the protection of Leishmania spp. against nitrosothiol-induced cytotoxicity

Glutathione is the major intracellular antioxidant thiol protecting mammalian cells against oxidative stress induced by oxygen- and nitrogen-derived reactive species. In trypanosomes and leishmanias, trypanothione plays a central role in parasite protection against mammalian host defence systems by...

Full description

Bibliographic Details
Main Author: Romão,P.R.T. (author)
Other Authors: Tovar,J. (author), Fonseca,S.G. (author), Moraes,R.H. (author), Cruz,A.K. (author), Hothersall,J.S. (author), Noronha-Dutra,A.A. (author), Ferreira,S.H. (author), Cunha,F.Q. (author)
Format: article
Language:eng
Published: 2006
Subjects:
Leishmania
Glutathione
Trypanothione
Trypanothione reductase
Nitric oxide
Free radicals
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000300006
Country:Brazil
Oai:oai:scielo:S0100-879X2006000300006

Internet

http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000300006

Similar Items