Effect of cyclooxygenase inhibitors on gentamicin-induced nephrotoxicity in rats
The frequent use of nonsteroidal anti-inflammatory drugs (NSAID) in combination with gentamicin poses the additional risk of nephrotoxic renal failure. Cyclooxygenase-1 (COX-1) is the main enzyme responsible for the synthesis of renal vasodilator prostaglandins, while COX-2 participates predominantl...
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| Other Authors: | , , |
| Format: | article |
| Language: | eng |
| Published: |
2004
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| Subjects: | |
| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000700006 |
| Country: | Brazil |
| Oai: | oai:scielo:S0100-879X2004000700006 |