Is the efflux pump inhibitor Verapamil a potential booster for isoniazid against Mycobacterium tuberculosis?

The membrane-based efflux pump systems are recognized to have an important role in pathogenicity and drug resistance in Mycobacterium tuberculosis by the extrusion of toxic substrates and drugs from the inner bacillus. This study aimed to investigate the in vitro interaction of Verapamil (VP), an ef...

Full description

Bibliographic Details
Main Author: Amaral, Renata Claro Ribeiro do (author)
Other Authors: Caleffi-Ferracioli, Katiany Rizzieri (author), Demitto, Fernanda de Oliveira (author), Almeida, Aryadne Larissa de (author), Siqueira, Vera Lucia Dias (author), Scodro, Regiane Bertin de Lima (author), Leite, Clarice Queico Fujimura (author), Pavan, Fernando Rogério (author), Cardoso, Rosilene Fressatti (author)
Format: article
Language:eng
Published: 2020
Subjects:
Tuberculosis
Multidrug-resistance
Efflux pumps
Efflux pumps inhibitors
Isoniazid
Online Access:https://doi.org/10.1590/s2175-97902020000218309
Country:Brazil
Oai:oai:revistas.usp.br:article/182070

Internet

https://doi.org/10.1590/s2175-97902020000218309

Similar Items