Is the efflux pump inhibitor Verapamil a potential booster for isoniazid against Mycobacterium tuberculosis?

The membrane-based efflux pump systems are recognized to have an important role in pathogenicity and drug resistance in Mycobacterium tuberculosis by the extrusion of toxic substrates and drugs from the inner bacillus. This study aimed to investigate the in vitro interaction of Verapamil (VP), an ef...

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Detalhes bibliográficos
Autor principal: Amaral, Renata Claro Ribeiro do (author)
Outros Autores: Caleffi-Ferracioli, Katiany Rizzieri (author), Demitto, Fernanda de Oliveira (author), Almeida, Aryadne Larissa de (author), Siqueira, Vera Lucia Dias (author), Scodro, Regiane Bertin de Lima (author), Leite, Clarice Queico Fujimura (author), Pavan, Fernando Rogério (author), Cardoso, Rosilene Fressatti (author)
Formato: article
Idioma:eng
Publicado em: 2020
Assuntos:
Tuberculosis
Multidrug-resistance
Efflux pumps
Efflux pumps inhibitors
Isoniazid
Texto completo:https://doi.org/10.1590/s2175-97902020000218309
País:Brasil
Oai:oai:revistas.usp.br:article/182070

Texto Completo

https://doi.org/10.1590/s2175-97902020000218309

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