Hepatic toxicity caused by PLGA-microspheres containing usnic acid from the lichen C ladonia substellata (AHTI) during pregnancy in Wistar rats

ABSTRACT This study aimed to evaluate the teratogenic and hepatotoxic potential of the usnic acid encapsulated into PLGA-microspheres. In total, 12 female Wistar rats in pregnancy were randomly distributed in the control group (n= 6) that received 1.0 mL of physiological solution and treatment group...

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Bibliographic Details
Main Author: MARINHO,KETSIA S.N. (author)
Other Authors: ANTONIO,ERIVALDO A. (author), SILVA,CAMILLA V.N.S. (author), SILVA,KEILA T. DA (author), TEIXEIRA,VALÉRIA W. (author), AGUIAR JUNIOR,FRANCISCO C.A. DE (author), SANTOS,KATHARINE R.P. DOS (author), SILVA,NICÁCIO H. DA (author), SANTOS,NOEMIA P.S. (author)
Format: article
Language:eng
Published: 2017
Subjects:
encapsulation
fetotoxicity
hepatotoxicity
secondary metabolite
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000301073
Country:Brazil
Oai:oai:scielo:S0001-37652017000301073

Internet

http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000301073

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