Epileptic manifestations induced by midazolam in the neonatal period

Antiepileptic drugs may cause worsening of epilepsy by aggravating pre-existing seizures or by triggering new seizure types. There are several reports of adverse effects related to midazolam, but only a few authors reported epileptic manifestations. We report four newborns seen at the Neonatal Inten...

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Bibliographic Details
Main Author: Montenegro,Maria Augusta (author)
Other Authors: Guerreiro,Marilisa M. (author), Caldas,Jamil Pedro Siqueira (author), Moura-Ribeiro,Maria Valeriana L. (author), Guerreiro,Carlos Alberto M. (author)
Format: article
Language:eng
Published: 2001
Subjects:
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000200018
Country:Brazil
Oai:oai:scielo:S0004-282X2001000200018
Description
Summary:Antiepileptic drugs may cause worsening of epilepsy by aggravating pre-existing seizures or by triggering new seizure types. There are several reports of adverse effects related to midazolam, but only a few authors reported epileptic manifestations. We report four newborns seen at the Neonatal Intensive Care Unit of our University Hospital, who developed seizures a few seconds after the administration of midazolam. It is difficult to identify the patients at risk, but it is important to be aware and recognize this situation.