Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer

Background Limitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation. Transcriptional regulation of hTERT is believed to play a major role in telomerase activation in human cancers. Main body The dominant inter...

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Bibliographic Details
Main Author: Leão, Ricardo (author)
Other Authors: Apolónio, Joana (author), Lee, Donghyun (author), Figueiredo, Arnaldo (author), Tabori, Uri (author), Castelo-Branco, Pedro (author)
Format: article
Language:eng
Published: 2018
Subjects:
Telomeres
Telomerase
Telomerase regulation
Cancer biomarkers
Online Access:http://hdl.handle.net/10400.1/10529
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/10529

Internet

http://hdl.handle.net/10400.1/10529

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