Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer

Background Limitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation. Transcriptional regulation of hTERT is believed to play a major role in telomerase activation in human cancers. Main body The dominant inter...

ver descrição completa

Detalhes bibliográficos
Autor principal: Leão, Ricardo (author)
Outros Autores: Apolónio, Joana (author), Lee, Donghyun (author), Figueiredo, Arnaldo (author), Tabori, Uri (author), Castelo-Branco, Pedro (author)
Formato: article
Idioma:eng
Publicado em: 2018
Assuntos:
Texto completo:http://hdl.handle.net/10400.1/10529
País:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/10529