Tissue optical clearing as a diagnostic tool for tissue pathology differentiation

With the objective of developing a diagnostic tool, we have used the immersion optical clearing method and studied normal and pathological tissues (cancer, diabetes) under treatment by optical clearing agents (OCAs). In order to quantify pathology status OCA diffusion properties in different tissues...

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Bibliographic Details
Main Author: Oliveira, Luís (author)
Other Authors: Carneiro, Isa (author), Carvalho, Sónia (author), Henrique, Rui (author), Tuchina, Daria (author), Timoshina, Polina (author), Bashkatov, Alexey (author), Genina, Elina (author), Tuchin, Valery (author)
Format: conferenceObject
Language:eng
Published: 2018
Subjects:
Optical clearing
Pathology
Diabetes
Cancer
Free and bound water
Diffusion coefficient
Pathology diagnosis
Online Access:http://hdl.handle.net/10400.22/11856
Country:Portugal
Oai:oai:recipp.ipp.pt:10400.22/11856
Description
Summary:With the objective of developing a diagnostic tool, we have used the immersion optical clearing method and studied normal and pathological tissues (cancer, diabetes) under treatment by optical clearing agents (OCAs). In order to quantify pathology status OCA diffusion properties in different tissues were measured. We have demonstrated that free water content in cancerous tissues is higher than in normal.

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