The Matrilineal Ancestry of Ashkenazi Jewry: Portrait of a Recent Founder Event

Both the extent and location of the maternal ancestral deme from which the Ashkenazi Jewry arose remain obscure. Here, using complete sequences of the maternally inherited mitochondrial DNA (mtDNA), we show that close to one-half of Ashkenazi Jews, estimated at 8,000,000 people, can be traced back t...

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Detalhes bibliográficos
Autor principal: Behar, DM (author)
Outros Autores: Metspalu, E (author), Kivisild, T (author), Achilli, A (author), Hadid, Y (author), Tzur, S (author), Pereira, L (author), Amorim, A (author), Quintana-Murci, L (author), Majamaa, K (author), Herrnstadt, C (author), Howell, N (author), Balanovsky, O (author), Kutuev, I (author), Pshenichnov, A (author), Gurwitz, D (author), Bonne-Tamir, B (author), Torroni, A (author), Villems, R (author), Skorecki, K (author)
Formato: article
Idioma:eng
Publicado em: 2006
Assuntos:
Base Sequence
DNA Mitochondrial/genetics
Female
Founder Effect
Humans
Jews/classification
Jews/ethnology
Jews/genetics
Male
Molecular Sequence Data
Phylogeny
Texto completo:http://hdl.handle.net/10216/109578
País:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/109578
Descrição
Resumo:Both the extent and location of the maternal ancestral deme from which the Ashkenazi Jewry arose remain obscure. Here, using complete sequences of the maternally inherited mitochondrial DNA (mtDNA), we show that close to one-half of Ashkenazi Jews, estimated at 8,000,000 people, can be traced back to only 4 women carrying distinct mtDNAs that are virtually absent in other populations, with the important exception of low frequencies among non-Ashkenazi Jews. We conclude that four founding mtDNAs, likely of Near Eastern ancestry, underwent major expansion(s) in Europe within the past millennium.

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