Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells

KRAS and BRAF mutations are frequent in colorectal carcinoma (CRC) and have the potential to activate proliferation and survival through MAPK/ERK and/or PI3K signalling pathways. Because diet is one of the most important determinants of CRC incidence and progression, we studied the effects of the di...

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Bibliographic Details
Main Author: Xavier, Cristina P. R. (author)
Other Authors: Lima, Cristóvão F. (author), Preto, Ana (author), Seruca, Raquel (author), Ferreira, Manuel Fernandes (author), Wilson, Cristina Pereira (author)
Format: article
Language:eng
Published: 2009
Subjects:
Flavonoids
Ursolic acid
Colorectal carcinoma
MAPK/ERK and PI3K pathways
Molecular nutrition
Science & Technology
Online Access:https://hdl.handle.net/1822/12236
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/12236

Internet

https://hdl.handle.net/1822/12236

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