Protection of tamoxifen against oxidation of mitochondrial thiols and NAD(P)H underlying the permeability transition induced by prooxidants

The effects of tamoxifen (TAM) were studied on the mitochondrial permeability transition (MPT) induced by the prooxidant tert-butyl hydroperoxide (t-BuOOH) or the thiol cross-linker phenylarsine oxide (PhAsO), in the presence of Ca2+, in order to clarify the mechanisms involved in the MPT inhibition...

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Detalhes bibliográficos
Autor principal: Cardoso, Carla M. P. (author)
Outros Autores: Almeida, Leonor M. (author), Custódio, José B. A. (author)
Formato: article
Idioma:eng
Publicado em: 2004
Assuntos:
Texto completo:http://hdl.handle.net/10316/5764
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/5764