Versatile synthesis of 5-aminoimidazole-4-carboxylic acid derivatives

5-Amino imidazole 4-substituted carboxamidines and 4-substituted imidoyl cyanides were selectively obtained under mild experimental conditions from reaction of the easily accessible 5-amino-4-cyanoformimidoyl imidazoles with primary aliphatic and aromatic amines, ammonia and amino acids in a one-pot...

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Detalhes bibliográficos
Autor principal: Dias, Alice (author)
Outros Autores: Vila-Chã, Sofia (author), Costa, Luísa (author), Cunha, Daniela (author), Senhorães, Nádia (author), Proença, M. Fernanda R. P. (author)
Formato: article
Idioma:eng
Publicado em: 2011
Assuntos:
Heterocycles
Imidazole
Carboxamidine
Carboximidate
Imidoyl cyanides
Science & Technology
Texto completo:http://hdl.handle.net/1822/15443
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/15443
Descrição
Resumo:5-Amino imidazole 4-substituted carboxamidines and 4-substituted imidoyl cyanides were selectively obtained under mild experimental conditions from reaction of the easily accessible 5-amino-4-cyanoformimidoyl imidazoles with primary aliphatic and aromatic amines, ammonia and amino acids in a one-pot reaction. When alcohols were used, the corresponding 5-aminoimidazole 4-carboximidates were isolated. An equally simple reaction occurred when starting imidazoles were combined with water to give 5-aminoimidazole 4-acyl cyanides.

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