The resting-brain of obsessive-compulsive disorder

Obsessive–compulsive disorder (OCD) is one of the most debilitating psychiatric conditions, having a dramatic impact on patients’ daily living. In this work, we aimed to explore resting-state functional connectivity in OCD patients, using an independent component analysis. Eighty individuals (40 pat...

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Bibliographic Details
Main Author: Moreira, Pedro Silva (author)
Other Authors: Marques, Paulo (author), Magalhães, Ricardo (author), Esteves, Madalena (author), Sousa, Nuno (author), Soares, José Miguel (author), Morgado, Pedro (author)
Format: article
Language:eng
Published: 2019
Subjects:
Obsessive-compulsive disorder
Resting-state networks
FMRI
Science & Technology
Online Access:http://hdl.handle.net/1822/62408
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/62408
Description
Summary:Obsessive–compulsive disorder (OCD) is one of the most debilitating psychiatric conditions, having a dramatic impact on patients’ daily living. In this work, we aimed to explore resting-state functional connectivity in OCD patients, using an independent component analysis. Eighty individuals (40 patients and 40 healthy controls) performed a resting state fMRI protocol. OCD patients displayed reduced functional connectivity (FC) in visual and sensorimotor networks. In addition, patients displayed decreased FC between sensory networks and increased FC between default-mode and cerebellar networks.

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