Catalytic one-pot diastereoselective Michael-initiated ring-closure of methyl ketones with 3-bromochromones: synthesis of cyclopropa[b]chromanones

A one-pot diastereoselective base-catalyzed Michael-initiated ring-closure (MIRC) of activated methyl ketones with 3-bromochromones to give cyclopropa[b]chromanones is described. Three asymmetric centres are generated in the new cyclopropa[b]chromanone skeleton. Stereochemistry studies based on NMR...

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Bibliographic Details
Main Author: Sousa, Joana L. C. (author)
Other Authors: Talhi, Oualid (author), Mendes, Ricardo F. (author), Paz, Filipe A. Almeida (author), Bachari, Khaldoun (author), Silva, Artur M. S. (author)
Format: article
Language:eng
Published: 2016
Subjects:
Oxygen heterocycles
Cyclopropanes
Small ring systems
Fused-ring systems
Michael addition
Cyclization
Online Access:http://hdl.handle.net/10773/18199
Country:Portugal
Oai:oai:ria.ua.pt:10773/18199

Internet

http://hdl.handle.net/10773/18199

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