Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury

After spinal cord injury (SCI), nerve regeneration is severely hampered due to the establishment of a highly inhibitory microenvironment at the injury site, through the contribution of multiple factors. The potential of antisense oligonucleotides (AONs) to modify gene expression at different levels,...

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Bibliographic Details
Main Author: Moreno, PM (author)
Other Authors: Ferreira, AR (author), Salvador, D (author), Rodrigues, MT (author), Torrado, M (author), Carvalho, ED (author), Tedebark, U (author), Sousa, MM (author), Amaral, IF (author), Wengel, J (author), Pêgo, AP (author)
Format: article
Language:eng
Published: 2018
Subjects:
LNA
antisense oligonucleotides
gapmer
hydrogel
in situ delivery
spinal cord injury
Online Access:https://hdl.handle.net/10216/121102
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/121102

Internet

https://hdl.handle.net/10216/121102

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