Bioengineered strategies for tendon regeneration

Their important mechanical function predisposes tendons to injury and rupture, becoming a worldwide clinical problem. Commonly injured tendons include the rotator cuff, finger flexors, patellar, and Achilles tendon [1]. As poor cellular and vascular tissues [2], tendons present some healing constrai...

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Detalhes bibliográficos
Autor principal: Gonçalves, Ana Isabel Silva (author)
Outros Autores: Rodrigues, Márcia T. (author), Reis, R. L. (author), Gomes, Manuela E. (author)
Formato: bookPart
Idioma:eng
Publicado em: 2016
Assuntos:
Texto completo:http://hdl.handle.net/1822/42477
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/42477
Descrição
Resumo:Their important mechanical function predisposes tendons to injury and rupture, becoming a worldwide clinical problem. Commonly injured tendons include the rotator cuff, finger flexors, patellar, and Achilles tendon [1]. As poor cellular and vascular tissues [2], tendons present some healing constraints, typically requiring surgical intervention. Available reparative surgeries rely on tissue replacement with auto- or allografts [3], which are often accompanied with donor site morbidity, pain, inferior functionalities, and eventually graft failure. Due to the market demand, commercial substitutes for tendon repair have been developed as biological and synthetic scaffolds.