Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner

TERT promoter mutations reactivate telomerase, allowing for indefinite telomere maintenance and enabling cellular immortalization. These mutations specifically recruit the multimeric ETS factor GABP, which can form two functionally independent transcription factor species: a dimer or a tetramer. We...

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Bibliographic Details
Main Author: Mancini, Andrew (author)
Other Authors: Magalhães, Ana Xavier Silva (author), Woods, Wendy S. (author), Nguyen, Kien-Thiet (author), Amen, Alexandra M. (author), Hayes, Josie L. (author), Fellmann, Christof (author), Gapinske, Michael (author), McKinney, Andrew M. (author), Hong, Chibo (author), Jones, Lindsey E. (author), Walsh, Kyle M. (author), Bell, Robert J. A. (author), Doudna, Jennifer A. (author), Costa, Bruno Marques (author), Song, Jun S. (author), Perez-Pinera, Pablo (author), Costello, Joseph F. (author)
Format: article
Language:eng
Published: 2018
Subjects:
Glioblastoma
TERT promoter mutation
GABP
Cancer immortality
Telomerase
Telomeres
Ciências Médicas::Medicina Básica
Science & Technology
Online Access:http://hdl.handle.net/1822/57876
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/57876

Internet

http://hdl.handle.net/1822/57876

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