The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease

Objective Compromised brain cholesterol turnover and altered regulation of brain cholesterol metabolism have been allied with some neurodegenerative diseases, including Huntington’s disease (HD). Following our previous studies in HD, in this study we aim to investigate in vitro in a neuroblastoma ce...

Full description

Bibliographic Details
Main Author: Nóbrega, Clévio (author)
Other Authors: Conceição, André (author), Costa, Rafael G (author), Koppenol, Rebekah (author), Sequeira, Raquel L. (author), Nunes, Ricardo (author), Carmo-Silva, Sara (author), Marcelo, Adriana (author), Matos, Carlos A (author), Betuing, Sandrine (author), Caboche, Jocelyne (author), Cartier, Nathalie (author), Alves, Sandro (author)
Format: article
Language:eng
Published: 2020
Online Access:http://hdl.handle.net/10400.1/13861
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/13861

Internet

http://hdl.handle.net/10400.1/13861

Similar Items