Structure-function studies of BPP-BrachyNH 2 and synthetic analogues thereof with Angiotensin I-Converting Enzyme

The vasoactive proline-rich oligopeptide termed BPP-BrachyNH2 (H-WPPPKVSP-NH2) induces in vitro inhibitory activity of angiotensin I-converting enzyme (ACE) in rat blood serum. In the present study, the removal of N-terminal tryptophan or C-terminal proline from BPP-BrachyNH2 was investigated in ord...

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Detalhes bibliográficos
Autor principal: Arcanjo, Daniel D.R. (author)
Outros Autores: Vasconcelos, Andreanne G. (author), Nascimento, Lucas A. (author), Mafud, Ana Carolina (author), Plácido, Alexandra (author), Alves, Michel M.M. (author), Delerue-Matos, Cristina (author), Bemquerer, Marcelo P. (author), Vale, Nuno (author), Gomes, Paula (author), Oliveira, Eduardo B. (author), Lima, Francisco C.A. (author), Mascarenhas, Yvonne P. (author), Carvalho, Fernando Aécio A. (author), Simonsen, Ulf (author), Ramos, Ricardo M. (author), Leite, José Roberto S.A. (author)
Formato: article
Idioma:eng
Publicado em: 2019
Assuntos:
Docking
Molecular dynamics simulations
Molecular mechanics
Poisson-Boltzmann surface area
g_mmpbsa
proline-Rich oligopeptide
Toxicological prediction
Texto completo:http://hdl.handle.net/10400.22/13537
País:Portugal
Oai:oai:recipp.ipp.pt:10400.22/13537

Texto Completo

http://hdl.handle.net/10400.22/13537

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