Targeting lactate transport suppresses in vivo breast tumour growth

Background: Most cancers, including breast cancer, have high rates of glucose consumption, associated with lactate production, a process referred as “Warburg effect”. Acidification of the tumour microenvironment by lactate extrusion, performed by lactate transporters (MCTs), is associated with highe...

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Bibliographic Details
Main Author: Morais-Santos, Filipa (author)
Other Authors: Granja, Sara (author), Miranda-Gonçalves, Vera (author), Moreira, António H.J. (author), Queirós, Sandro (author), Vilaça, João L. (author), Schmitt, Fernando C. (author), Longatto-Filho, Adhemar (author), Paredes, Joana (author), Baltazar, Fátima (author), Pinheiro, Céline (author)
Format: article
Language:eng
Published: 2016
Subjects:
monocarboxylate transporters
breast carcinoma
hypoxia, lactate
warburg effect
Online Access:http://hdl.handle.net/11110/997
Country:Portugal
Oai:oai:ciencipca.ipca.pt:11110/997

Internet

http://hdl.handle.net/11110/997

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