Targeting lactate transport suppresses in vivo breast tumour growth

Background: Most cancers, including breast cancer, have high rates of glucose consumption, associated with lactate production, a process referred as “Warburg effect”. Acidification of the tumour microenvironment by lactate extrusion, performed by lactate transporters (MCTs), is associated with highe...

ver descrição completa

Detalhes bibliográficos
Autor principal: Morais-Santos, Filipa (author)
Outros Autores: Granja, Sara (author), Miranda-Gonçalves, Vera (author), Moreira, António H.J. (author), Queirós, Sandro (author), Vilaça, João L. (author), Schmitt, Fernando C. (author), Longatto-Filho, Adhemar (author), Paredes, Joana (author), Baltazar, Fátima (author), Pinheiro, Céline (author)
Formato: article
Idioma:eng
Publicado em: 2016
Assuntos:
monocarboxylate transporters
breast carcinoma
hypoxia, lactate
warburg effect
Texto completo:http://hdl.handle.net/11110/997
País:Portugal
Oai:oai:ciencipca.ipca.pt:11110/997

Texto Completo

http://hdl.handle.net/11110/997

Registos relacionados