Experimental evolution of resistance to artemisinin combination therapy results in amplification of the mdr1 gene in a rodent malaria parasite

BACKGROUND: Lacking suitable alternatives, the control of malaria increasingly depends upon Artemisinin Combination Treatments (ACT): resistance to these drugs would therefore be disastrous. For ACTs, the biology of resistance to the individual components has been investigated, but experimentally in...

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Bibliographic Details
Main Author: Rodrigues, Louise A (author)
Other Authors: Henriques, Gisela (author), Borges, Sofia T (author), Hunt, Paul (author), Sanchez, Cecília P (author), Martinelli, Axel (author), Cravo, Pedro (author)
Format: article
Language:eng
Published: 2021
Subjects:
Animals
Antimalarials
Artemisinins
Blotting, Western
Drug Resistance
Malaria
Mefloquine
Mice
Multidrug Resistance-Associated Proteins
Plasmodium chabaudi
Polymerase Chain Reaction
Protozoan Proteins
Sequence Analysis, DNA
Journal Article
Research Support, Non-U.S. Gov't
Genetics
Ecology, Evolution, Behavior and Systematics
Parasitology
Infectious Diseases
SDG 3 - Good Health and Well-being
Online Access:http://hdl.handle.net/10362/117235
Country:Portugal
Oai:oai:run.unl.pt:10362/117235

Internet

http://hdl.handle.net/10362/117235

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