A molecular switch in the scaffold NHERF1 enables misfolded CFTR to evade the peripheral quality control checkpoint

The peripheral protein quality control (PPQC) checkpoint removes improperly folded proteins from the plasma membrane through a mechanism involving the E3 ubiquitin ligase CHIP (carboxyl terminus of Hsc70 interacting protein). PPQC limits the efficacy of some cystic fibrosis (CF) drugs, such as VX-80...

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Bibliographic Details
Main Author: Loureiro, Cláudia (author)
Other Authors: Matos, Ana Margarida (author), Dias-Alves, Ãngela (author), Pereira, Joana Filipa (author), Uliyakina, Irina (author), Barros, Patrícia (author), Amaral, Margarida (author), Matos, Paulo (author)
Format: article
Language:eng
Published: 2015
Subjects:
Vias de Transdução de Sinal e Patologias Associadas
Fibrose Quísitica
GTPase Rac1
Protein Folding
Online Access:http://hdl.handle.net/10400.18/3072
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/3072

Internet

http://hdl.handle.net/10400.18/3072

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