Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models

Parkinson disease (PD) is a neurodegenerative disorder characterized by the abnormal intracellular accumulation of SNCA/α-synuclein. While the exact mechanisms underlying SNCA pathology are not fully understood, increasing evidence suggests the involvement of autophagic as well as lysosomal deficien...

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Bibliographic Details
Main Author: Prieto Huarcaya, Susy (author)
Other Authors: Drobny, Alice (author), Marques, André R A (author), Di Spiezio, Alessandro (author), Dobert, Jan Philipp (author), Balta, Denise (author), Werner, Christian (author), Rizo, Tania (author), Gallwitz, Lisa (author), Bub, Simon (author), Stojkovska, Iva (author), Belur, Nandkishore R (author), Fogh, Jens (author), Mazzulli, Joseph R (author), Xiang, Wei (author), Fulzele, Amitkumar (author), Dejung, Mario (author), Sauer, Markus (author), Winner, Beate (author), Rose-John, Stefan (author), Arnold, Philipp (author), Saftig, Paul (author), Zunke, Friederike (author)
Format: article
Language:eng
Published: 2022
Subjects:
alpha-synuclein
cathepsin D
lysosomal degradation
lysosomal storage disorders
parkinson disease
synucleinopathies
SDG 3 - Good Health and Well-being
Online Access:http://hdl.handle.net/10362/135842
Country:Portugal
Oai:oai:run.unl.pt:10362/135842

Internet

http://hdl.handle.net/10362/135842

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