Nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/chitosan scaffolds for skin regeneration

The purpose of this study was to evaluate hybrid poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/chitosan nanofibrous mats as scaffolds for skin engineering. In vitro studies were carried out to test the potential of the scaffolds for fibroblasts adhesion, viability, and proliferation (L929 cell...

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Bibliographic Details
Main Author: Veleirinho, B. (author)
Other Authors: Coelho, D.S. (author), Dias, P.F. (author), Maraschin, M. (author), Ribeiro-do-Valle, R.M. (author), Lopes da Silva, J.A. (author)
Format: article
Language:eng
Published: 2012
Subjects:
PHBV
chitosan
electrospinning
scaffold
skin healing
Online Access:http://hdl.handle.net/10773/9578
Country:Portugal
Oai:oai:ria.ua.pt:10773/9578
Description
Summary:The purpose of this study was to evaluate hybrid poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/chitosan nanofibrous mats as scaffolds for skin engineering. In vitro studies were carried out to test the potential of the scaffolds for fibroblasts adhesion, viability, and proliferation (L929 cell line). The in vivo performance was also studied in a full-thickness wound healing model. PHBV/chitosan 4:1 w/w exhibited a higher in vitro biocompatibility and a better ability for cell adhesion and growth, compared to PHBV/chitosan 2:3 w/w. The in vivo assay also revealed the better performance of this scaffold, improving the wound healing process in rats.

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