Nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/chitosan scaffolds for skin regeneration

The purpose of this study was to evaluate hybrid poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/chitosan nanofibrous mats as scaffolds for skin engineering. In vitro studies were carried out to test the potential of the scaffolds for fibroblasts adhesion, viability, and proliferation (L929 cell...

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Detalhes bibliográficos
Autor principal: Veleirinho, B. (author)
Outros Autores: Coelho, D.S. (author), Dias, P.F. (author), Maraschin, M. (author), Ribeiro-do-Valle, R.M. (author), Lopes da Silva, J.A. (author)
Formato: article
Idioma:eng
Publicado em: 2012
Assuntos:
PHBV
chitosan
electrospinning
scaffold
skin healing
Texto completo:http://hdl.handle.net/10773/9578
País:Portugal
Oai:oai:ria.ua.pt:10773/9578
Descrição
Resumo:The purpose of this study was to evaluate hybrid poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/chitosan nanofibrous mats as scaffolds for skin engineering. In vitro studies were carried out to test the potential of the scaffolds for fibroblasts adhesion, viability, and proliferation (L929 cell line). The in vivo performance was also studied in a full-thickness wound healing model. PHBV/chitosan 4:1 w/w exhibited a higher in vitro biocompatibility and a better ability for cell adhesion and growth, compared to PHBV/chitosan 2:3 w/w. The in vivo assay also revealed the better performance of this scaffold, improving the wound healing process in rats.

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