iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

The apical inflammatory cytokine TNF regulates numerous important biological processes including inflammation and cell death, and drives inflammatory diseases. TNF secretion requires TACE (also called ADAM17), which cleaves TNF from its transmembrane tether. The trafficking of TACE to the cell surfa...

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Bibliographic Details
Main Author: Oikonomidi, Ioanna (author)
Other Authors: Burbridge, Emma (author), Cavadas, Miguel (author), Sullivan, Graeme (author), Collis, Blanka (author), Naegele, Heike (author), Clancy, Danielle (author), Brezinova, Jana (author), Hu, Tianyi (author), Bileck, Andrea (author), Gerner, Christopher (author), Bolado, Alfonso (author), Kriegsheim, Alex Von (author), Martin, Seamus J. (author), Steinberg, Florian (author)
Format: article
Language:eng
Published: 2019
Subjects:
iTAP
IRhom interactor
TACE
TNF
Online Access:http://hdl.handle.net/10400.7/912
Country:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/912

Internet

http://hdl.handle.net/10400.7/912

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