Structural and enzymatic characterization of ABgp46, a novel phage endolysin with broad anti-Gram-negative bacterial activity

The present study demonstrates the antibacterial potential of a phage endolysin against Gram-negative pathogens, particularly against multidrug resistant strains of Acinetobacter baumannii. We have cloned, heterologously expressed and characterized a novel endolysin (ABgp46) from Acinetobacter phage...

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Bibliographic Details
Main Author: Oliveira, Hugo Alexandre Mendes (author)
Other Authors: Boas, Diana Patrícia Andrade Vilas (author), Mesnage, Stéphane (author), Kluskens, Leon (author), Lavigne, Rob (author), Sillankorva, Sanna (author), Secundo, Francesco (author), Azeredo, Joana (author)
Format: article
Language:eng
Published: 2016
Subjects:
Acinetobacter baumannii
Phage endolysins
Mass spectrometry
Circular dichroism
Antibacterial activity
Ciências Agrárias::Biotecnologia Agrária e Alimentar
Science & Technology
Online Access:http://hdl.handle.net/1822/41411
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/41411

Internet

http://hdl.handle.net/1822/41411

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