Synthesis, docking, enzymatic and cellular assays of thieno[3,2-b]pyridine-thioether-1,3-diarylureas as VEGFR2 inhibitors

Vascular endothelial growth factor receptor 2 (VEGFR2) is a class of tyrosine kinase receptors, expressed primarily in endothelial cells , and is activated by the specific binding of VEGF to the VEGFR2 extracellular regulatory domain, undergoing autophosphorylation, triggering signaling pathways lea...

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Bibliographic Details
Main Author: Queiroz, Maria João R.P. (author)
Other Authors: Peixoto, Daniela (author), Calhelha, Ricardo C. (author), Abreu, Rui M.V. (author), Froufe, Hugo J.C. (author), Ferreira, Isabel C.F.R. (author), Costa, Raquel (author), Soares, Raquel (author)
Format: conferenceObject
Language:eng
Published: 2013
Online Access:http://hdl.handle.net/10198/7899
Country:Portugal
Oai:oai:bibliotecadigital.ipb.pt:10198/7899

Internet

http://hdl.handle.net/10198/7899

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