The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma

The lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in glioma, the most common primary brain tumors, and its clinical relevance. HOTAIR gene expression, methylation, copy-number and prognostic value...

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Bibliographic Details
Main Author: Xavier-Magalhães, Ana (author)
Other Authors: Gonçalves, Céline S (author), Fogli, Anne (author), Lourenço, Tatiana (author), Pojo, Marta (author), Pereira, Bruno (author), Rocha, Miguel (author), Celeste Lopes, Maria (author), Crespo, Inês (author), Rebelo, Olinda (author), Tão, Herminio (author), Lima, João (author), Moreira, Ricardo (author), Pinto, Afonso A (author), Jones, Chris (author), Reis, Rui M. (author), Costello, Joseph F (author), Arnaud, Philippe (author), Sousa, Nuno (author), Costa, Bruno Marques (author)
Format: article
Language:eng
Published: 2018
Subjects:
HOTAIR
glioblastoma
glioma
prognosis
HOXA9
Online Access:http://hdl.handle.net/1822/61532
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/61532

Internet

http://hdl.handle.net/1822/61532

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