MCT1, MCT4 and CD147 expression and 3-bromopyruvate toxicity in colorectal cancer cells are modulated by the extracellular conditions

Monocarboxylate transporters (MCTs) inhibition leads to disruption in glycolysis, induces cell death and decreases cell invasion, revealing the importance of MCT activity in intracellular pH homeostasis and tumor aggressiveness. 3-Bromopyruvate (3BP) is an anti-tumor agent, whose uptake occurs via M...

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Bibliographic Details
Main Author: Pereira-Vieira, Joana (author)
Other Authors: Azevedo-Silva, Joao (author), Preto, Ana (author), Casal, Margarida (author), Queiros, Odilia (author)
Format: article
Language:eng
Published: 2019
Subjects:
3-bromopyruvate
colorectal cancer
monocarboxylate transporters
Warburg effect
Ciências Naturais::Ciências Biológicas
Science & Technology
Online Access:http://hdl.handle.net/1822/72947
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/72947

Internet

http://hdl.handle.net/1822/72947

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