Cardiac cytochrome c and cardiolipin depletion during anthracycline-induced chronic depression of mitochondrial function

It is still unclear why anthracycline treatment results in a cardiac-specific myopathy. We investigated whether selective doxorubicin (DOX) cardiotoxicity involving mitochondrial degeneration is explained by different respiratory complexes reserves between tissues by comparing and contrasting treatm...

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Bibliographic Details
Main Author: Pereira, Gonçalo C. (author)
Other Authors: Pereira, Susana P. (author), Tavares, Ludgero C. (author), Carvalho, Filipa S. (author), Magalhães-Novais, Sílvia (author), Barbosa, Inês A. (author), Santos, Maria S. (author), Bjork, James (author), Moreno, António J. (author), Wallace, Kendall B. (author), Oliveira, Paulo J. (author)
Format: article
Language:eng
Published: 2016
Subjects:
Animals
Antibiotics, Antineoplastic
Cardiolipins
Cytochromes c
Doxorubicin
Kidney
Liver
Male
Mitochondria
Mitochondrial Myopathies
Myocardium
Rats, Wistar
Online Access:http://hdl.handle.net/10316/47559
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/47559
Description
Summary:It is still unclear why anthracycline treatment results in a cardiac-specific myopathy. We investigated whether selective doxorubicin (DOX) cardiotoxicity involving mitochondrial degeneration is explained by different respiratory complexes reserves between tissues by comparing and contrasting treatment effects in heart vs liver and kidney. Alternatively, we have also explored if the degeneration is due to alterations of mitochondrial thresholds to incompatible states.

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