Intracellular trafficking of AIP56, an NF-κB-cleaving toxin from Photobacterium damselae subsp. Piscicida

AIP56 (apoptosis-inducing protein of 56 kDa) is a metalloprotease AB toxin secreted by Photobacterium damselae subsp. piscicida that acts by cleaving NF-κB. During infection, AIP56 spreads systemically and depletes phagocytes by postapoptotic secondary necrosis, impairing the host phagocytic defense...

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Bibliographic Details
Main Author: Pereira, LM (author)
Other Authors: Pinto, RD (author), Silva, DS (author), Moreira, AR (author), Beitzinger, C (author), Oliveira, P (author), Sampaio, P (author), Benz, R (author), Azevedo, JE (author), Santos, NM (author), Vale, A (author)
Format: article
Language:eng
Published: 2014
Subjects:
Animals
Apoptosis
Apoptosis Regulatory Proteins/metabolism
Bacterial Toxins/metabolism
Cell Survival
Cells, Cultured
Cytosol/chemistry
Endocytosis
Endosomes/chemistry
Hydrogen-Ion Concentration
Macrophages/microbiology
Macrophages/physiology
Male
Mice, Inbred C57BL
Microscopy, Confocal
NF-kappa B/metabolism
Peptide Hydrolases/metabolism
Photobacterium/metabolism
Protein Transport
Proteolysis
Online Access:http://hdl.handle.net/10216/114494
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/114494

Internet

http://hdl.handle.net/10216/114494

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