BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury

Neuron-targeted gene delivery is a promising strategy to treat peripheral neuropathies. Here we propose the use of polymeric nanoparticles based on thiolated trimethyl chitosan (TMCSH) to mediate targeted gene delivery to peripheral neurons upon a peripheral and minimally invasive intramuscular admi...

ver descrição completa

Detalhes bibliográficos
Autor principal: Lopes, C (author)
Outros Autores: Gonçalves, N (author), Gomes, C (author), Saraiva, MJ (author), Pêgo, AP (author)
Formato: article
Idioma:eng
Publicado em: 2017
Assuntos:
Brain-derived neurotrophic factor
Gene therapy
Neuron-targeted nanoparticles
Neuropathies
Neuroprotection
Trimethyl chitosan
Texto completo:https://hdl.handle.net/10216/120724
País:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/120724

Texto Completo

https://hdl.handle.net/10216/120724

Registros relacionados