Clonal evolution of CD8+ T cell responses against latent viruses: relationship among phenotype, localization, and function

Human cytomegalovirus (hCMV) infection is characterized by a vast expansion of resting effector-type virus-specific T cells in the circulation. In mice, interleukin-7 receptor α (IL-7Rα)-expressing cells contain the precursors for long-lived antigen-experienced CD8(+) T cells, but it is unclear if s...

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Bibliographic Details
Main Author: Remmerswaal, EB (author)
Other Authors: Klarenbeek, PL (author), Alves, NL (author), Doorenspleet, ME (author), Schaik, BD (author), Esveldt, RE (author), Idu, MM (author), Leeuwen, EM (author), der, Bom-Baylon, N (author), Kampen, AH (author), Koch, SD (author), Pircher, H (author), Bemelman, FJ (author), Ten, Brinke, A (author), Baas, F (author), Ten, Berge, IJ (author), Lier, RA (author), de, Vries, N (author)
Format: article
Language:eng
Published: 2015
Subjects:
Adolescent
Adult
Aged
Animals
CD8-Positive T-Lymphocytes/chemistry
CD8-Positive T-Lymphocytes/classification
CD8-Positive T-Lymphocytes/immunology
Clonal Evolution
Cytomegalovirus/immunology
Cytomegalovirus/physiology
Female
Flow Cytometry
Humans
Male
Mice
Middle Aged
Receptors, Interleukin-7/analysis
T-Lymphocyte Subsets/chemistry
T-Lymphocyte Subsets/classification
T-Lymphocyte Subsets/immunology
Virus Latency
Young Adult
Online Access:http://hdl.handle.net/10216/114504
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/114504

Internet

http://hdl.handle.net/10216/114504

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