Plasma membrane-specific interactome analysis reveals calpain 1 as a druggable modulator of rescued Phe508del-CFTR cell surface stability

Cystic fibrosis (CF) is a genetic disease caused by mutations in the gene encoding CF transmembrane conductance regulator (CFTR), a chloride channel normally expressed at the surface of epithelial cells. The most frequent mutation, resulting in Phe-508 deletion, causes CFTR misfolding and its premat...

Full description

Bibliographic Details
Main Author: Matos, Ana Margarida (author)
Other Authors: Pinto, Francisco R. (author), Barros, Patrícia (author), Amaral, Margarida D. (author), Pepperkok, Rainer (author), Matos, Paulo (author)
Format: conferenceObject
Language:eng
Published: 2020
Subjects:
Cystic Fibrosis
CFTR
Caplain
Vias de Transdução de Sinal e Patologias Associadas
Online Access:http://hdl.handle.net/10400.18/6682
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/6682

Internet

http://hdl.handle.net/10400.18/6682

Similar Items