Sirolimus ameliorates cyclosporin-induced nephrotoxicity in a rat model – focus on renal lesions, oxidative stress, inflammation, proliferation and angiogenesis

Sirolimus (SRL) have been pointed as a feasible option for minimize the use of cyclosporine A (CsA), especially because os putatively less nephrotoxicity. However, the cellular mechanism underlying the renoprotection remains to be elucidated, and the clinical data is yet insufficient. This stuty aim...

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Detalhes bibliográficos
Autor principal: Sereno, José (author)
Outros Autores: Romão, Ana M. (author), Teixeira, Margarida (author), Parada, Belmiro (author), Santos, Paulo R. (author), Alves, Rui (author), Mega, Cristina (author), Vala, Helena (author), Lemos, Edite T. (author), Teixeira, Frederico (author), Reis, Flávio (author)
Formato: conferenceObject
Idioma:eng
Publicado em: 2015
Assuntos:
nephropathy
Sirolimus (SRL)
cyclosporine A (CsA)
nephrotoxicity
Texto completo:http://hdl.handle.net/10400.19/2729
País:Portugal
Oai:oai:repositorio.ipv.pt:10400.19/2729
Descrição
Resumo:Sirolimus (SRL) have been pointed as a feasible option for minimize the use of cyclosporine A (CsA), especially because os putatively less nephrotoxicity. However, the cellular mechanism underlying the renoprotection remains to be elucidated, and the clinical data is yet insufficient. This stuty aimed to characterize the histological lesions and the molecular pathways implicated in CsA-induced nephropathy and prevention when converted to SRL.

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