In Silico, In Vitro and In Vivo Toxicological Assessment of BPP-BrachyNH2, A Vasoactive Proline-Rich Oligopeptide from Brachycephalus ephippium

BPP-BrachyNH2 is a proline-rich oligopeptide (PRO) firstly identified in skin secretion of the frog Brachycephalus ephippium, which possess in vitro inhibitory activity of angiotensin-I converting enzyme (ACE) and endothelium-dependent vasorelaxant activity. Considering its potential application in...

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Bibliographic Details
Main Author: Arcanjo, Daniel D. R. (author)
Other Authors: Mafud, Ana Carolina (author), Vasconcelos, Andreanne G. (author), Silva-Filho, José Couras da (author), Amaral, Maurício P. M. (author), Brito, Lucas M. (author), Bemquerer, Marcelo P. (author), Kückelhaus, Selma A. S. (author), Plácido, Alexandra (author), Delerue-Matos, Cristina (author), Vale, Nuno (author), Mascarenhas, Yvonne P. (author), Carvalho, Fernando Aécio A. (author), Oliveira, Aldeidia P. (author), Leite, José Roberto Souza Almeida (author)
Format: article
Language:eng
Published: 2019
Subjects:
Cytotoxicity
MTT
In silico
pkCSM
Proline-rich oligopeptide
Toxicological
Online Access:http://hdl.handle.net/10400.22/13629
Country:Portugal
Oai:oai:recipp.ipp.pt:10400.22/13629

Internet

http://hdl.handle.net/10400.22/13629

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