A catalytic route to dibenzodiazepines involving Buchwald-Hartwig coupling: reaction scope and mechanistic consideration

We report a new synthetic method for the synthesis of a family of dibenzodiazepines (DBDAs), employing Pd-catalyzed C-N coupling of o-bromoaldimine, with o-bromoaniline as the key step. Eleven DBDAs were prepared, containing electron-withdrawing groups (CN, F, NO2) and electron-donating groups (OMe)...

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Bibliographic Details
Main Author: Burke, Anthony (author)
Other Authors: Marques, CAROLINA (author), Peixoto, Daniela (author), Locati, Abel (author), Goth, Albertino (author), Ramalho, João Paulo (author)
Format: article
Language:eng
Published: 2016
Subjects:
Catálise
medicina
Online Access:http://hdl.handle.net/10174/16623
Country:Portugal
Oai:oai:dspace.uevora.pt:10174/16623

Internet

http://hdl.handle.net/10174/16623

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