Targeting of lanthanide(III) chelates of DOTA-type glycoconjugates to the hepatic asyaloglycoprotein receptor: cell internalization and animal imaging studies

The characterization of a new class of hydrophilic liver-targeted agents for gamma-scintigraphy and MRI, consisting, respectively, of [153Sm]3+ or Gd3+ complexes of DOTA monoamide or bisamide linked glycoconjugates (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), is reported. In vi...

Full description

Bibliographic Details
Main Author: Prata, M. I. M. (author)
Other Authors: Santos, A. C. (author), Torres, Susana (author), André, João P. (author), Martins, J. A. R. (author), Neves, M. (author), García Martín, M. L. (author), Rodrigues, T. B. (author), López Larrubia, P. (author), Cerdán, S. (author), Geraldes, Carlos F. G. C. (author)
Format: article
Language:eng
Published: 2006
Subjects:
Magnetic resonance imaging
Contrast agents
Gadolinium
Glycoconjugates
Liver targeting
Asialoglycoprotein receptor
Gamma imaging
gamma scintigraphy
Science & Technology
Online Access:http://hdl.handle.net/1822/5960
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/5960

Internet

http://hdl.handle.net/1822/5960

Similar Items